Sedating antidepressants remeron

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Mirtazapine is not usually used as a first line antidepressant; rather, it is often added to duloxetine or venlefaxine to treat severe or resistant depression.The usual starting dose for mirtazapine is 15 mg/day at bedtime.It also blocks 3 serotonin receptors:5HT2A, 5HT2C, and 5HT3. Alpha 2 receptors are autoreceptors which tend to be inhibitory.

At low doses, sedation and weight gain may be significant.

These can be good if you want sedation and weight gain, but a problem if you don't want these side effects.

Mirtazapine is particularly good for patients for whom you want a drug which helps with nausea, sedation and weight gain.

might decrease the apnea–hypopnea index in those with significant sleep-disordered breathing suggests that this agent should be considered in patients who have insomnia comorbid with sleep-disordered breathing.

Currently, practice guidelines recommend SSRIs and some of the newer antidepressants (e.g., buproprion, nefazodone, and venlafaxine) as first choice antidepressants given their relatively modest side effect profile.

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